ChatGPT can be used to handle event registrations by generating registration forms, answering frequently asked questions about the event, providing information about the event schedule, and sending event reminders to the attendees. It can also assist in processing and organizing registration data, sending confirmation emails to the attendees, and handling any changes or cancellations. ChatGPT's natural language processing capabilities can help simplify the registration process for both the event organizers and attendees, making it more efficient and user-friendly.